Page last updated: 2024-09-05

vx-745 and [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone

vx-745 has been researched along with [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone in 1 studies

Compound Research Comparison

Studies (vx-745)	Trials (vx-745)	Recent Studies (post-2010) (vx-745)	Studies ([4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone)	Trials ([4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone)	Recent Studies (post-2010) ([4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone)
58	1	35	9	0	7

Protein Interaction Comparison

Protein	Taxonomy	[4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone (IC50)
Mitogen-activated protein kinase 13	Homo sapiens (human)	0.026
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	0.039
Mitogen-activated protein kinase 12	Homo sapiens (human)	0.026
Mitogen-activated protein kinase 11	Homo sapiens (human)	0.026
Mitogen-activated protein kinase 14	Homo sapiens (human)	0.0282

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aaes, H; Binderup, L; Björkling, F; Fjording, MS; Ottosen, ER; Skak-Nielsen, T; Sørensen, MD	1

Other Studies

1 other study(ies) available for vx-745 and [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone

Article	Year
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Dermatitis, Contact; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-2; Leukocytes, Mononuclear; Ligands; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Peroxidase; Structure-Activity Relationship; Tumor Necrosis Factor-alpha	2003

Article

Year

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.

Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Dermatitis, Contact; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-2; Leukocytes, Mononuclear; Ligands; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Peroxidase; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2003